Namura S: Effects of chronic systemic treatment with peroxisome proliferator-activated receptor alpha activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide

Rupture of a cerebral aneurysm causes subarachnoid hemorrhage (SAH). Primary treatment for the patients who survived the initial rupture is prevention of second rupture. Even if the aneurismal obliteration, by either surgical or endovascular interventions, is successful, many complications follow. Neurological deterioration due to delayed cerebral ischemia (DCI) is a major consequence responsible for the mortality/morbidity of SAH and resists, in many patients, to the currently recommended therapies. Multiple factors seem to contribute to DCI. This exploratory project will test our hypothesis that combination of betaine and fenofibrate may be a potential candidate for preventing DCI after SAH.